6 edition of Improved Exposure Assessment on Existing Cancer Studies found in the catalog.
January 15, 2006
by American Water Works Research Foundation
Written in English
|The Physical Object|
|Number of Pages||231|
Since IARC classified shift-work into 2A, probably carcinogenic,15 there has been much scientific and public interest in the topic, and scientific interest in better epidemiological studies that could reduce the existing uncertainty in the body of studies done to date by use of improved and refined exposure assessment. This was the motivation. To improve the exposure assessment and to evaluate the degree of uncertainty in the different steps, the underlying information in that process needs to be documented for studies conducted in.
Research Gaps Research Ongoing 1. Case-control studies of childhood cancer with improved exposure assessment taking into account all major fixed point sources of RF exposure (base stations, AM, FM, TV antennas, and other sources). HUMAN LABORATORY STUDIES Research Needs There are some significant research needs for human laboratory studies. In June , Robert N. Hoover, M.D., Sc.D., Director of the Epidemiology and Biostatistics program, retired from the Division of Cancer Epidemiology and Genetics (DCEG) after a remarkable 48 years of service to the National Cancer Institute (NCI). He is widely known as an international leader in cancer epidemiology and expert in hormonal carcinogenesis, a visionary .
In February , Laufey Amundadottir, Ph.D., was awarded scientific tenure by the NIH, and promoted to senior investigator in the Laboratory of Translational Genomics (LTG).Dr. Amundadottir investigates inherited genetic risk factors that contribute to the etiology of pancreatic cancer and survival for patients with the malignancy. Finally, a series of studies of Australian Vietnam veterans yielded information on cancer risk. These studies, too, were limited by small sample sizes, by the absence of detailed exposure assessment, and at least initially by the relatively young age of the veteran populations. As the Vietnam veterans continue to age, additional research.
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Title(s): Improved exposure assessment on existing cancer studies/ prepared by Gary Amy [et al.] ; jointly sponsored by AWWA Research Foundation and U.S. Environmental Protection Agency. Country of Publication: United States Publisher: Denver, CO: AWWA Research Foundation and American Water Works Association, c Of the three studies, Schullehner et al.
() presents a nation-wide assessment of colorectal cancer risk in Denmark coupled with reliable individually linked exposure data. For the assessment of other types of cancer risk related to nitrate, we used a kidney cancer risk scenario from Ward et al.
() for a cohort that included both men and Cited by: Improved Exposure Assessment on Existing Cancer Studies. Report # 09/08/ 09/08/ View Executive Summary. Subscriber Improved Exposure Assessment on Existing Cancer Studies.
Publication. 09/08/ 09/08/ Related Projects. Recently. Project # Drinking Water Disinfection By-Products and Pregnancy Outcome. Increased exposure to disinfection by-products (DBP) in public drinking water supplies has also been associated with increased bladder cancer risk in studies in North America and Europe (Cantor ; Cantor et al.
; Costet et al. The relationship between bladder cancer risk and other drinking water contaminants has not been as well Cited by: Cancer risk assessment based on the two-year rodent tumor bioassay is becoming obsolete due to the complexities associated exposure to polycyclic aromatic hydrocarbons (PAHs) exposures from occupational, dietary, and environmental settings.
In addition to the costs and time factors involved, the assessment at best only infers the relationship. Following these first studies, case-control studies with markedly improved exposure assessment at the individual level were conducted.
The studies on bladder cancer reported the most consistent positive associations with chlorination by-products exposure and indicate an increased risk at trihalomethane (THM) levels commonly observed in.
Amy et al. performed an updated exposure assessment for two of the previous studies (Cantor et al. ; King and Marrett ) by applying expert knowledge regarding formation of CxDBPs to use available water quality and DBP data to better model past exposures, improve exposure assessment for THMs, and add estimates for selected CxDBPs.
Lower gastrointestinal cancer studies: The association between the human gut microbiome and colorectal cancer (CRC) is an important focus of our research. In a case-control study with data and fecal specimens previously collected in DCEG, we found that CRC cases had reduced fecal microbiome alpha diversity, increased carriage of Fusobacterium.
exposure is unlikely to act as a tumour initiator. Fur ther, a variety of cancer studies using animals have sought evidence of an effect of RF exposure on spontaneous or natural cancer rates, the enhancement of the effects of known carcinogens or effects on the growth of implanted tumours.
However, they have rovided equivocalp. Since the discovery of acrylamide in foods ina number of studies have explored its potential as a human carcinogen. This article outlines a systematic review of dietary acrylamide and human cancer, acrylamide exposure and internal dose, exposure assessment methods in the epidemiologic studies, existing data gaps, and future directions.
urred in studies carried out so far, primarily related to exposure assessment. Self-reported use of mobile phone appears to be imprecise. The relationship between the amount of mobile phone use and the radio-frequency field is unclear.
Several factors affect the strength of the radio-frequency field emitted by the phone, and accommodating their effect has the potential to improve exposure.
o Development of a GIS for specific ecologic or analytic epidemiologic studies o Development of a GIS for exposure assessment to use in future, ongoing, or existing epidemiologic studies.
Applications in Cancer Control o Cancer and cancer control surveillance: monitor emerging trends in cancer- related health behaviors, incidence, mortality, or. The results indicate that paving asphalt emissions have a reduced dermal cancer potency compared to roofing asphalt, consistent with the lower levels of the multi-ringed PAHs implicated in cancer risks.
Based on existing occupational exposure studies, cancer risks to pavers from both dermal and inhalation exposure to asphalt emissions is within.
Steven R. Patierno, in Abeloff's Clinical Oncology (Sixth Edition), Fibers Asbestos. The appearance of lung cancer in patients exposed to asbestosis was first reported in the s.
Early epidemiologic studies were limited by various deficiencies in exposure assessment, but gradually studies showed increased lung cancer risk in workers with potential exposure to asbestos during mining.
Exposure assessment is important in all environmental-epidemiologic studies. A wide range of exposure-assessment strategies and techniques are available for use in environmental-epidemiologic investigation.
Associations have been clarified by improved use of exposure assessment even where indirect methods have been used. Consumption of fatty fish might reduce the risk of prostate cancer, although epidemiological studies of fish consumption are rare.
We studied the association between fish consumption and prostate cancer in a population-based prospective cohort of Swedish men. During 30 years of follow-up, men who ate no fish had a two-fold to three-fold higher frequency of prostate cancer than those who.
Legislation. On July 7,the Firefighter Cancer Registry Act (H.R. ) was was signed by the president and became public law. This bill requires the Centers for Disease Control and Prevention (CDC) to develop and maintain a voluntary registry of firefighters to collect history and occupational information that can be linked to existing data in state cancer registries.
Radiation-related Exposure Assessment Studies Investigators work to identify, understand, and quantify the risk of cancer in populations exposed to medical, occupational, or environmental radiation, and to advance understanding of radiation carcinogenesis.
Tobacco smoke exposure may be associated with increased breast cancer risk, although the evidence supporting the association is inconclusive. We conducted a case-control study in Delaware, incorporating detailed exposure assessment for active and secondhand smoke at home and in the workplace.
Primary invasive breast cancer cases diagnosed among female Delaware residents, ages. The approach to exposure assessment and the use of estimated exposures in data analysis are key elements in epidemiological studies of all environmental exposures and were a central focus of the subcommittee's review of the literature of arsenic in drinking water and risk of cancer.
The group, comprising cancer and occupational/ environmental epidemiologists as well as environmental scientists, identified and discussed immediate research needs (to be achieved within 5 years) for improved exposure assessment in environment-cancer studies.Visit to get more information about this book, to buy it in print, or to download it as a free PDF.
Under the Safe Drinking Water Act, the U.S. Environmental Protection Agency (EPA) is required to establish exposure standards for contaminants in public drinking-water systems that might.
Exposure assessment in these studies was generally based on crude exposure metrics, such as “low” versus “high” exposure probability combinations of heterogeneous job titles. Details of study design and exposure assessment for the studies reviewed are summarized in Table 1.